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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPR2 All Species: 40
Human Site: S647 Identified Species: 80
UniProt: P20594 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P20594 NP_003986.2 1047 117022 S647 S S H G S L K S S N C V V D S
Chimpanzee Pan troglodytes XP_001168194 1047 116964 S647 S S H G S L K S S N C V V D S
Rhesus Macaque Macaca mulatta XP_001085221 1047 116990 S647 S S H G S L K S S N C V V D S
Dog Lupus familis XP_531993 999 112273 S622 Y G L A S F R S T A E P D D S
Cat Felis silvestris
Mouse Mus musculus Q6VVW5 1047 117039 S647 S S H G S L K S S N C V V D S
Rat Rattus norvegicus P16067 1047 117109 S647 S S H G S L K S S N C V V D S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517544 743 84256 G401 P T M G M Q K G D V Y S F G I
Chicken Gallus gallus
Frog Xenopus laevis NP_001084176 1082 122776 S683 G S H G N L K S S N C V V D S
Zebra Danio Brachydanio rerio XP_689479 1088 124806 S689 G S H G N L K S S N C V V D S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q07553 1163 130896 S655 I S H G N L R S S N C L I D S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09435 1137 128085 S687 R L H G N L R S A T C L V N D
Sea Urchin Strong. purpuratus P16065 1125 126238 S696 K S H G H L K S S N C V V D N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.8 89.1 N.A. 98.5 98.5 N.A. 64.5 N.A. 72.2 58.1 N.A. 32.5 N.A. 28.7 36.2
Protein Similarity: 100 99.9 100 90 N.A. 99.4 99.3 N.A. 67 N.A. 82.9 69.7 N.A. 49 N.A. 46.7 52.2
P-Site Identity: 100 100 100 26.6 N.A. 100 100 N.A. 13.3 N.A. 86.6 86.6 N.A. 66.6 N.A. 40 80
P-Site Similarity: 100 100 100 40 N.A. 100 100 N.A. 20 N.A. 93.3 93.3 N.A. 93.3 N.A. 73.3 86.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 0 0 0 9 9 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 84 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 9 0 0 0 9 84 9 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % E
% Phe: 0 0 0 0 0 9 0 0 0 0 0 0 9 0 0 % F
% Gly: 17 9 0 92 0 0 0 9 0 0 0 0 0 9 0 % G
% His: 0 0 84 0 9 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 0 0 0 0 0 0 0 0 0 0 9 0 9 % I
% Lys: 9 0 0 0 0 0 75 0 0 0 0 0 0 0 0 % K
% Leu: 0 9 9 0 0 84 0 0 0 0 0 17 0 0 0 % L
% Met: 0 0 9 0 9 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 34 0 0 0 0 75 0 0 0 9 9 % N
% Pro: 9 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % P
% Gln: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % Q
% Arg: 9 0 0 0 0 0 25 0 0 0 0 0 0 0 0 % R
% Ser: 42 75 0 0 50 0 0 92 75 0 0 9 0 0 75 % S
% Thr: 0 9 0 0 0 0 0 0 9 9 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 9 0 67 75 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _